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Pharmacological studies

LSL offers efficacy/usefulness studies of cosmetics/beauty equipment/food
to support your product development.

  • Type of study
  • Animals
  • Duration of the study

Download study request form

Laser-induced choroidal neovascularization (CNV) model

  • Mice or rats

    Approx. 2 months

Intraocular pressure (IOP) measurement

  • Normotensive IOP models
     

    Cynomolgus monkeys, beagles or rabbits

    Approx. 1.5 months
     

  • Ocular hypertension models

    Cynomolgus monkeys or rats

    Approx. 1.5 months

  • Laser-induced ocular hypertension model

    Cynomolgus monkeys

    Approx. 1.5 months

  • Water loading-induced ocular hypertension model

    Rabbits
     

    Approx. 1.5 months
     

Water loading-induced retinal ischemia model

  • Rats

    Approx. 3 months

Light-induced retinal degeneration model

  • Rats

    Approx. 3 months

Dry eye model

  • Rabbits
     

    Approx. 1.5 months
    (winter only)

Bioequivalency tests (ophthalmic solutions, etc.)

Efficacy studies of cosmetics/beauty equipment
※Studies measuring TEWL and those using skin surface hygrometers and sebumeters are also available.

  • Whitening studies

    Brown guinea pigs

    Approx. 2.5 months

  • Wrinkle-improving studies

    Hairless mice (wrinkle model)

    Approx. 6 months

  • UV light-induced skin stress inhibitory studies

    Brown guinea pigs
     

    Approx. 3 months
     

  • Hair growth studies

    C3H mice

    Approx. 3 months

  • Rough skin studies

    Mice (rough skin model)

    Approx. 2 months

Efficacy studies of food

  • Efficacy studies for obesity

    Zucker rats (obesity model), etc.

  • Palatability studies of pet food

    Dogs or cats

In addition to these studies, LSL challenges various studies. Please feel free to consult us.

Download study request form

Studies in humans

Clinical studies, including patch tests (safety tests), usage tests and sensory analysis, are conducted in Japanese subjects. Studies in a small number of subjects (TEWL, moisture, sebum, etc.) are also available.

  • Type of study
  • Number of subjects
  • Duration of the study

Download study request form

Human patch test(24/48 hours)

  • 20/40

    Approx. 1 month

Moisture test

  • 8 or more

    Approx. 1 month

Stinging test(for labeling of cosmetics)

  • 6

    Approx. 1 month

Sensory analysis

  • 5

※Please consult us for other usage tests, sensory analysis, etc.
※Please feel free to consult us regarding details, costs and duration of the studies (free quotation)

Download study request form

Safety studies

Useful for application of cosmetics/quasi drugs for approval, acquisition of SEK and SIAA marks, development of functional food and agrichemicals, preparation of MSDS, compiling in-house data, and so on.

  • Type of study
  • Animals/bacterial strains/cells
  • Duration of the study

Download study request form

Single dose toxicity studies
※Please consult us regarding the route of administration (percutaneous, intravenous, etc.).

  • Single dose level (2000 mg/kg) studies (limit tests)

    Mice or rats (≥5/sex)
     

    Approx. 1 month
     

  • Dose range finding studies (OECD Guideline)

    Mice or rats (≥5/sex/group)
     

    Approx. 1.5 months
     

  • Dose range finding studies (for pesticide registration)

    Quails (≥5/sex/group)
     

    Approx. 1.5 months
     

Repeated oral dose toxicity studies
※Please consult us regarding the duration of the study and dose levels (number of groups).

  • Mice or rats (≥5/sex/group)

    At least 3 months

Primary skin irritation studies

  • Rabbits (≥3)

    Approx. 1 month

Cumulative skin irritation studies(14-day continuous application)

  • Guinea pigs or rabbits (≥3)

    Approx. 1.5 months

Phototoxicity studies(Morikawa’s method)

  • Guinea pigs (≥5)

    Approx. 1 month

Skin sensitization studies(Maximization Test/Adjuvant and Patch Test/Buehler Test)

  • Guinea pigs (≥5/group)

    Approx. 2 months

Photosensitization studies(Adjuvant and Strip Test)

  • Guinea pigs (≥5/group)

    Approx. 2 months

Mucosal irritation studies

  • Rabbits or guinea pigs

    Approx. 3 months

Eye irritation studies

  • Rabbits

    Approx. 3 months

Genotoxicity studies

  • Ames tests (bacterial reverse mutation tests)

    5 bacterial strains
     

    Approx. 1 month
     

  • Chromosomal aberration tests

    Cultured Chinese hamster cells

    Approx. 3 months

  • Micronucleus tests

    Mice or rats

    Approx. 2 months

  • Cytotoxicity studies

    V79 cells (JCRB0603)

    Approx. 1 month

  • Ichthyotoxicity studies

    Japanese rice fish (7/group)

    Approx. 1 month

Please feel free to consult us regarding details, costs, etc. of the studies (free quotation).

Download study request form

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