Cosmetics and Quasi-drugs

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For application of cosmetics and quasi-drugs

Guide to Quasi-drug and Cosmetic Regulations in Japan 2011-12

  • Type of study
  • Animals/bacterial strains/cells
  • Number of participants
  • Duration of the study

Download study request form

Single oral dose toxicity(at a single dose level of 2000 mg/kg)

  • ≥ 5 rats or mice/sex

    Approx. 1 month

Primary skin irritation

  • 3 male rabbits

    Approx. 1 month

Cumulative skin irritation(14-day continuous application)

  • 3 female guinea pigs

    Approx. 1.5 months

Phototoxicity(Morikawa’s method)

  • 5 guinea pigs

    Approx. 1 month

Skin sensitization(Maximization/Adjuvant and Patch/Buehler Tests)

  • 20 female guinea pigs
    (25 female guinea pigs for the Buehler Test)

    Approx. 2 months

Photosensitization(Adjuvant and Strip Test)

  • 20 female guinea pigs

    Approx. 2 months

Eye irritation

  • 3 male rabbits

    Approx. 1 month


  • Ames test (bacterial reverse mutation test)

    5 bacterial strains

    Approx. 1 month

  • Chromosomal aberration test

    Cultured Chinese hamster cells

    Approx. 3 months

Human patch test(24-hour closed patch test)

  • 40 participants

    Approx. 1 month

Our services also include tests in Japanese participants for labeling of “Stinging tested”.
Please feel free to consult us regarding the details and costs of the studies and so forth (free quotation).